Characteristics of large patient‐reported outcomes: where can one million seizures get us?

V Ferastraoaru, DM Goldenholz, S Chiang… - Epilepsia …, 2018 - Wiley Online Library
Objective To analyze data from Seizure Tracker, a large electronic seizure diary, including
comparison of seizure characteristics among different etiologies, temporal patterns in …

Seizure diaries for clinical research and practice: limitations and future prospects

RS Fisher, DE Blum, B DiVentura, J Vannest… - Epilepsy & Behavior, 2012 - Elsevier
PURPOSE: An NINDS-sponsored conference in April of 2011 reviewed issues in epilepsy
clinical trials. One goal was to clarify new electronic methods for recording seizure …

Assessing seizure burden in pediatric epilepsy using an electronic medical record–based tool through a common data element approach

MP Fitzgerald, MC Kaufman, SL Massey… - …, 2021 - Wiley Online Library
Objective Improvement in epilepsy care requires standardized methods to assess disease
severity. We report the results of implementing common data elements (CDEs) to document …

Is seizure frequency variance a predictable quantity?

DM Goldenholz, SR Goldenholz, R Moss… - Annals of clinical …, 2018 - Wiley Online Library
Background There is currently no formal method for predicting the range expected in an
individual's seizure counts. Having access to such a prediction would be of benefit for …

[HTML][HTML] Counting seizures: The primary outcome measure in epileptology from the patients' perspective

B Blachut, C Hoppe, R Surges, J Stahl, CE Elger… - Seizure, 2015 - Elsevier
Purpose Patient-reported seizure counts represent a key outcome measure for individual
treatments and clinical studies in epileptology. Video-EEG based research, however …

Seizure cycles in focal epilepsy

MG Leguia, RG Andrzejak, C Rummel, JM Fan… - JAMA …, 2021 - jamanetwork.com
Importance Focal epilepsy is characterized by the cyclical recurrence of seizures, but, to our
knowledge, the prevalence and patterns of seizure cycles are unknown. Objective To …

A big data approach to the development of mixed‐effects models for seizure count data

JJ Tharayil, S Chiang, R Moss, JM Stern… - …, 2017 - Wiley Online Library
Objective Our objective was to develop a generalized linear mixed model for predicting
seizure count that is useful in the design and analysis of clinical trials. This model also may …

Use of an online epilepsy diary to characterize repetitive seizures

RS Fisher, E Bartfeld, JA Cramer - Epilepsy & Behavior, 2015 - Elsevier
Significance Little is known about patterns of seizures that occur multiple times a day,
sometimes called clusters or serial seizures. Objective The online diary, My Epilepsy Diary …

Epilepsy as a dynamic disease: A Bayesian model for differentiating seizure risk from natural variability

S Chiang, M Vannucci, DM Goldenholz, R Moss… - Epilepsia …, 2018 - Wiley Online Library
Objective A fundamental challenge in treating epilepsy is that changes in observed seizure
frequencies do not necessarily reflect changes in underlying seizure risk. Rather, changes in …

Who seizes longest? Impact of clinical and demographic factors

E Kaufmann, M Seethaler, M Lauseker, M Fan… - …, 2020 - Wiley Online Library
Objective To investigate the impact of clinical and demographic parameters on the duration
of focal onset seizures with and without secondary generalization using precise duration …