Epigenetics is a relatively recent field of molecular biology that has arisen over the past 25
years. Cancer is now understood to be a disease of widespread epigenetic dysregulation …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

Epigenetics refers to heritable changes in gene expression that are, unlike mutations, not
attributable to alterations in DNA sequence. Two predominant epigenetic mechanisms are …

Gastric cancer (GC) is one of the most common cancers and the second leading cause of
cancer-related mortality. Increasing discoveries have highlighted aberrant epigetic …

The cancer epigenome is characterized by global DNA methylation and chromatin changes,
such as the hypermethylation of specific CpG island promoters. Epigenetic agents like DNA …

Colorectal cancer (CRC) is a worldwide health concern with respect to both incidence and
mortality, and as a result, CRC tumorigenesis, progression and metastasis have been …

Colorectal cancer, a leading cause of mortality worldwide, is a multistep disorder that results
from the alteration of genetic and epigenetic mechanisms under contextual influence …

Recent studies provide compelling evidence that epigenetic dysregulation is involved in
almost every step of tumor development and progression. Differences in tumor behavior …

Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase
inhibitors (HDACi), are approved in monotherapy for cancer treatment. These drugs …

Epigenetic alterations contribute significantly to the development and progression of gastric
cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the …