Phage display: an overview in context to drug discovery
Peptides are emerging as a new reliable class of therapeutics and, thanks to their lower cost
of production, they are becoming established as perfect drug aspirants. Here, we briefly …
of production, they are becoming established as perfect drug aspirants. Here, we briefly …
Phage display as a technology delivering on the promise of peptide drug discovery
Highlights•We review phage display for use in producing therapeutic peptides/
peptidomimetics.•Generation of diverse peptide/protein phage libraries (∼ 10 9 clones) is …
peptidomimetics.•Generation of diverse peptide/protein phage libraries (∼ 10 9 clones) is …
Phage display-derived peptides as therapeutic alternatives to antibodies
RC Ladner, AK Sato, J Gorzelany, M de Souza - Drug discovery today, 2004 - Elsevier
Peptide-based drugs are now viable alternatives to biopharmaceuticals, such as antibodies.
Most of the past limitations of peptides have been removed by new technologies, so that …
Most of the past limitations of peptides have been removed by new technologies, so that …
Is phage display technology on target for developing peptide-based cancer drugs?
LA Landon, J Zou, SL Deutscher - Current drug discovery …, 2004 - ingentaconnect.com
New tumor targeting agents are required to advance cancer diagnosis and treatment.
Bacteriophage (phage) display technology, a molecular genetic means of combinatorial …
Bacteriophage (phage) display technology, a molecular genetic means of combinatorial …
Progress in phage display: evolution of the technique and its applications
T Bratkovič - Cellular and molecular life sciences, 2010 - Springer
Phage display, the presentation of (poly) peptides as fusions to capsid proteins on the
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …
Identification of cancer targets and therapeutics using phage display.
R Brissette, JK Prendergast… - Current opinion in drug …, 2006 - europepmc.org
Phage display is a well-established approach for the identification of bioactive peptides and
antibody fragments through the use of high diversity libraries. One major advantage of …
antibody fragments through the use of high diversity libraries. One major advantage of …
Peptide phage display: molecular principles and biomedical applications
MS Zambrano-Mila, KES Blacio, NS Vispo - Therapeutic innovation & …, 2020 - Springer
Phage display (PD) is a technology based on the presentation of functional exogenous
peptides on the capsid surface of bacteriophages. PD is performed by introducing a DNA …
peptides on the capsid surface of bacteriophages. PD is performed by introducing a DNA …
The use of phage display peptide libraries for basic and translational research
R Brissette, NI Goldstein - Cancer genomics and proteomics: Methods and …, 2007 - Springer
Phage display is a molecular technique, whereby genes are displayed in a functional form
on the outer surfaces of bacteriophages by fusion to viral coat proteins. The gene product is …
on the outer surfaces of bacteriophages by fusion to viral coat proteins. The gene product is …
From peptides to drugs via phage display
In the past ten years, there has been a flurry of research generating and screening
combinatorial peptide libraries. Molecular biologists have favored phage display as a means …
combinatorial peptide libraries. Molecular biologists have favored phage display as a means …
Bacteriophage display and discovery of peptide leads for drug development
HB Lowman - Annual review of biophysics and biomolecular …, 1997 - annualreviews.org
▪ Abstract Phage display makes large-peptide diversity libraries readily attainable for
identifying novel peptide ligands for receptors and other protein or non-protein targets. This …
identifying novel peptide ligands for receptors and other protein or non-protein targets. This …