Phage display: an overview in context to drug discovery

S Mimmi, D Maisano, I Quinto, E Iaccino - Trends in pharmacological …, 2019 - cell.com
Peptides are emerging as a new reliable class of therapeutics and, thanks to their lower cost
of production, they are becoming established as perfect drug aspirants. Here, we briefly …

Phage display as a technology delivering on the promise of peptide drug discovery

M Hamzeh-Mivehroud, AA Alizadeh, MB Morris… - Drug discovery today, 2013 - Elsevier
Highlights•We review phage display for use in producing therapeutic peptides/
peptidomimetics.•Generation of diverse peptide/protein phage libraries (∼ 10 9 clones) is …

Phage display-derived peptides as therapeutic alternatives to antibodies

RC Ladner, AK Sato, J Gorzelany, M de Souza - Drug discovery today, 2004 - Elsevier
Peptide-based drugs are now viable alternatives to biopharmaceuticals, such as antibodies.
Most of the past limitations of peptides have been removed by new technologies, so that …

Is phage display technology on target for developing peptide-based cancer drugs?

LA Landon, J Zou, SL Deutscher - Current drug discovery …, 2004 - ingentaconnect.com
New tumor targeting agents are required to advance cancer diagnosis and treatment.
Bacteriophage (phage) display technology, a molecular genetic means of combinatorial …

Progress in phage display: evolution of the technique and its applications

T Bratkovič - Cellular and molecular life sciences, 2010 - Springer
Phage display, the presentation of (poly) peptides as fusions to capsid proteins on the
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …

Identification of cancer targets and therapeutics using phage display.

R Brissette, JK Prendergast… - Current opinion in drug …, 2006 - europepmc.org
Phage display is a well-established approach for the identification of bioactive peptides and
antibody fragments through the use of high diversity libraries. One major advantage of …

Peptide phage display: molecular principles and biomedical applications

MS Zambrano-Mila, KES Blacio, NS Vispo - Therapeutic innovation & …, 2020 - Springer
Phage display (PD) is a technology based on the presentation of functional exogenous
peptides on the capsid surface of bacteriophages. PD is performed by introducing a DNA …

The use of phage display peptide libraries for basic and translational research

R Brissette, NI Goldstein - Cancer genomics and proteomics: Methods and …, 2007 - Springer
Phage display is a molecular technique, whereby genes are displayed in a functional form
on the outer surfaces of bacteriophages by fusion to viral coat proteins. The gene product is …

From peptides to drugs via phage display

BK Kay, AV Kurakin, R Hyde-DeRuyscher - Drug Discovery Today, 1998 - Elsevier
In the past ten years, there has been a flurry of research generating and screening
combinatorial peptide libraries. Molecular biologists have favored phage display as a means …

Bacteriophage display and discovery of peptide leads for drug development

HB Lowman - Annual review of biophysics and biomolecular …, 1997 - annualreviews.org
▪ Abstract Phage display makes large-peptide diversity libraries readily attainable for
identifying novel peptide ligands for receptors and other protein or non-protein targets. This …