Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However,
the mechanisms by which Bcl-w participates in the regulation of apoptosis in the testis are …

To explore physiological roles of BCL-W, a prosurvival member of the BCL-2 protein family,
we generated transgenic (TG) mice overexpressing Bcl-w driven by a chicken β-actin …

Expression of bcl-w, a close relative of bcl-2 is essential for male fertility in mice. Although
the initial wave of spermatogenesis in bcl-w−/− mice proceeds normally until 3–4 weeks of …

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐
2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell density‐related apoptosis …

A large part of germ cells die apoptotically during testicular development in rodents. In the
present study, a wave of germ cell apoptosis was observed between days 10 and 30 of …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

The proto-oncoprotein Cbl is known to control several signaling processes. It is highly
expressed in the testis, and because spermatogenesis is androgen dependent, we …

Anti-apoptotic members of the Bcl-2 family, such as Bcl-w, maintain cell viability by
preventing the activation of the cell death effectors, the caspases. Gene targeting …

We investigated the frequency of spontaneous apoptosis and expression of the Bcl-2 family
of proteins during normal spermatogenesis in man. Testicular tissue with both normal …

Abstract Bcl-2-related anti-and proapoptotic proteins are important in the decision step of the
intracellular death program upstream from the caspase proteases. Targeted overexpression …