Effect of formulation variables and gamma sterilization on transcorneal permeation and stability of proniosomal gels as ocular platforms for antiglaucomal drug
This study aims to evaluate the effect of different formulation variables (surfactant type and
HLB value) adopting full factorial design (5 1. 2 1) using coacervation phase technique on in …
HLB value) adopting full factorial design (5 1. 2 1) using coacervation phase technique on in …
Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies
Context: Vesicular drug carriers for ocular delivery have gained a real potential.
Proniosomal gels as ocular drug carriers have been proven to be an effective way to …
Proniosomal gels as ocular drug carriers have been proven to be an effective way to …
Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic …
Glaucoma is the second cause of blindness worldwide. Frequent administration of traditional
topical dosage forms may lead to patient incompliance and failure of treatment. Our study …
topical dosage forms may lead to patient incompliance and failure of treatment. Our study …
Development of loteprednol etabonate-loaded cationic nanoemulsified in-situ ophthalmic gel for sustained delivery and enhanced ocular bioavailability
A novel cationic nanoemulsified in-situ ophthalmic gel of loteprednol etabonate (LE) was
developed to improve the permeability and retention time of formulations for overall …
developed to improve the permeability and retention time of formulations for overall …
Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery
Background: Several in situ gel-forming systems have been developed to prolong the
precorneal residence time of a drug and to improve ocular bioavailability. Poloxamer 407 …
precorneal residence time of a drug and to improve ocular bioavailability. Poloxamer 407 …
Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept
Context: The conventional liquid ophthalmic delivery systems exhibit short pre-corneal
residence time and the relative impermeability to the cornea which leads to poor ocular …
residence time and the relative impermeability to the cornea which leads to poor ocular …
Design, formulation and evaluation of carboxy methyl tamarind based in situ gelling ophthalmic drug delivery system of dorzolamide hydrochloride
FS Dasankoppa, S Kujur, HPNA Sholapur… - Indian Journal of …, 2016 - journals.lww.com
Materials and Methods: In the present investigation, an attempt has been made to design,
formulate, and evaluate in situ gelling-based ophthalmic drug delivery system dorzolamide …
formulate, and evaluate in situ gelling-based ophthalmic drug delivery system dorzolamide …
Influence of hydroxypropylmethylcellulose and poloxamer composite on developed ophthalmic in situ gel: Ex vivo and in vivo characterization
R Barse, C Kokare, A Tagalpallewar - Journal of Drug Delivery Science and …, 2016 - Elsevier
The present study was planned to investigate the effect of polymer composites HPMC K15 M
and poloxamer 407 on developed dorzolamide hydrochloride in situ gel. Formulations were …
and poloxamer 407 on developed dorzolamide hydrochloride in situ gel. Formulations were …
Formulation and optimization of cationic nanoemulsions for enhanced ocular delivery of dorzolamide hydrochloride using Box-Behnken design: In vitro and in vivo …
The present study was designed to develop dorzolamide HCl (DRZ) loaded cationic
nanoemulsions (CNEs) for enhanced ocular delivery. CNEs were prepared employing high …
nanoemulsions (CNEs) for enhanced ocular delivery. CNEs were prepared employing high …
[PDF][PDF] Design, development and evaluation of cationic guar and hydroxypropyl guar based in-situ gels for ophthalmic drug delivery
FS Dasankoppa, NG Swamy - Indian Drugs, 2013 - researchgate.net
The poor bioavailability and therapeutic response exhibited by the conventional eye drops
due to rapid corneal loss is overcome by the use of ion-activated gel forming systems that …
due to rapid corneal loss is overcome by the use of ion-activated gel forming systems that …