Sex specific molecular networks and key drivers of Alzheimer's disease
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …
neurodegenerative disorder that affects women disproportionally. However, the underlying …
[HTML][HTML] Sex differences in Alzheimer's disease: insights from the multiomics landscape
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over
the course of disease development. The literature provides some evidence of sex-specific …
the course of disease development. The literature provides some evidence of sex-specific …
Sex-stratified single-cell RNA-Seq analysis identifies sex-specific and cell type-specific transcriptional responses in Alzheimer's disease across two brain regions
Alzheimer's disease (AD) is a pervasive neurodegenerative disorder that disproportionately
affects women. Since neural anatomy and disease pathophysiology differ by sex …
affects women. Since neural anatomy and disease pathophysiology differ by sex …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
Mechanisms of sex differences in Alzheimer's disease
C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
Sex-specific cross tissue meta-analysis identifies immune dysregulation in women with Alzheimer's disease
MD Paranjpe, S Belonwu, JK Wang… - Frontiers in Aging …, 2021 - frontiersin.org
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common cause of dementia in the United States. In spite of evidence of females having …
most common cause of dementia in the United States. In spite of evidence of females having …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
[HTML][HTML] Alzheimer's risk factors age, APOE genotype, and sex drive distinct molecular pathways
Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD):
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …
age, APOE genotype, and sex. Here, we present comprehensive datasets and analyses of …
Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer's disease
JM Winkler, HS Fox - BMC systems biology, 2013 - Springer
Background Alzheimer's disease is the most prevalent form of dementia. While a number of
transcriptomic studies have been performed on the brains of Alzheimer's specimens, no …
transcriptomic studies have been performed on the brains of Alzheimer's specimens, no …
Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains
D Marques-Coelho, LCC Iohan… - npj Aging and …, 2021 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …
pathophysiological processes involved in AD onset and progression are still poorly …