[HTML][HTML] Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications
L Zou, M Liao, Y Zhen, S Zhu, X Chen, J Zhang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target: Miniperspective
L Zhang, L Ouyang, Y Guo, J Zhang… - Journal of Medicinal …, 2018 - ACS Publications
UNC-51-like kinase 1 (ULK1), known as an ortholog of the yeast Atg1, is the serine–
threonine kinase and the autophagic initiator in mammals. Accumulating evidence has …
threonine kinase and the autophagic initiator in mammals. Accumulating evidence has …
Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)
A Chaikuad, SE Koschade, A Stolz… - Biochemical …, 2019 - portlandpress.com
Autophagy is essential for cellular homeostasis and when deregulated this survival
mechanism has been associated with disease development. Inhibition of autophagy …
mechanism has been associated with disease development. Inhibition of autophagy …
UNC51‐like kinase 1, autophagic regulator and cancer therapeutic target
Autophagy, the cell process of self‐digestion, plays a pivotal role in maintaining energy
homoeostasis and protein synthesis. When required, it causes degradation of long‐lived …
homoeostasis and protein synthesis. When required, it causes degradation of long‐lived …
Regulation and function of uncoordinated-51 like kinase proteins
EY Chan - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Significance: The Atg1/ULK1 (uncoordinated-51 like kinase 1) protein complex
plays an essential role regulating autophagy in mammalian cells. As autophagy is …
plays an essential role regulating autophagy in mammalian cells. As autophagy is …
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates
DF Egan, MGH Chun, M Vamos, H Zou, J Rong… - Molecular cell, 2015 - cell.com
Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …
[HTML][HTML] Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation
F Nazio, M Carinci, C Valacca, P Bielli… - The Journal of cell …, 2016 - ncbi.nlm.nih.gov
Autophagy is an intracellular degradation pathway whose levels are tightly controlled to
secure cell homeostasis. Unc-51–like kinase 1 (ULK1) is a conserved serine–threonine …
secure cell homeostasis. Unc-51–like kinase 1 (ULK1) is a conserved serine–threonine …
Canonical and noncanonical functions of ULK/Atg1
Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of
serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 …
serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 …
The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
EJ Lee, C Tournier - Autophagy, 2011 - Taylor & Francis
Autophagy is an evolutionarily conserved physiological process of self-digestion by a cell to
adapt to various stresses, including starvation. Its molecular basis involves the concerted …
adapt to various stresses, including starvation. Its molecular basis involves the concerted …
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction
ABSTRACT ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase
that plays a key role in regulating macroautophagy/autophagy induction in response to …
that plays a key role in regulating macroautophagy/autophagy induction in response to …