Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

UNC-51-like kinase 1 (ULK1), known as an ortholog of the yeast Atg1, is the serine–
threonine kinase and the autophagic initiator in mammals. Accumulating evidence has …

Autophagy is essential for cellular homeostasis and when deregulated this survival
mechanism has been associated with disease development. Inhibition of autophagy …

Autophagy, the cell process of self‐digestion, plays a pivotal role in maintaining energy
homoeostasis and protein synthesis. When required, it causes degradation of long‐lived …

Abstract Significance: The Atg1/ULK1 (uncoordinated-51 like kinase 1) protein complex
plays an essential role regulating autophagy in mammalian cells. As autophagy is …

Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy
as a potential broadly applicable cancer therapy. ULK1/Atg1 is the only serine/threonine …

Autophagy is an intracellular degradation pathway whose levels are tightly controlled to
secure cell homeostasis. Unc-51–like kinase 1 (ULK1) is a conserved serine–threonine …

Mammalian Unc-51-like kinases 1 and 2 (ULK1 and ULK2) belong to the ULK/Atg1 family of
serine/threonine kinases, which are conserved from yeast to mammals. Although ULK/Atg1 …

Autophagy is an evolutionarily conserved physiological process of self-digestion by a cell to
adapt to various stresses, including starvation. Its molecular basis involves the concerted …

ABSTRACT ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase
that plays a key role in regulating macroautophagy/autophagy induction in response to …