Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) which are
broadly expressed in the central nervous system (CNS) and other tissues in the periphery …

Allosteric modulators of muscarinic receptors act at a site apart from the common ligand
binding site of the receptor protein. These compounds affect both of the molecular events …

Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the
treatment of multiple CNS disorders. The high degree of conservation of amino acids …

Disruption of cholinergic signalling via muscarinic receptors is associated with various
pathologies, like Alzheimer's disease or schizophrenia. Selective muscarinic agonists …

Allosteric modulation of G protein-coupled receptors has been intensively studied at
muscarinic acetylcholine receptors. Findings made with archetypal allosteric agents such as …

The muscarinic acetylcholine receptors are a subfamily of G protein-coupled receptors that
regulate numerous fundamental functions of the central and peripheral nervous system. The …

The five subtypes of the muscarinic acetylcholine receptor (mAChR1—5 or M1—5) are
differentially expressed G protein-coupled receptors (GPCRs) important to a variety of …

Allosteric modulators of ligand-receptor interactions are found for a variety of receptors
(Christopoulos, 2002). Allosteric agents attach to a binding site being topographically …

Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated
from the orthosteric binding site for the endogenous neurotransmitter. Allosteric modulators …

The cholinergic signalling system has been an attractive pathway to seek targets for
modulation of arousal, cognition, and attention which are compromised in …