This thesis would not have been possible without the love, support, guidance, and
encouragement of many individuals. I would like to express my deepest gratitude to my …

Aim of work: To demonstrate the bleomycin induced histological changes in the lung and the
possible protective and/or therapeutic effect of stem cell therapy. Materials and methods …

Background: Lung fibrosis is considered as an end stage for many lung diseases including
lung inflammatory disease, autoimmune diseases and malignancy. There are limited …

Bleomycin is a cancer chemotherapeutic agent that induces pulmonary fibrosis. Vitamin D
plays an immunomodulation role. Bone marrow-derived mesenchymal stem cells have a …

Background: Bleomycin (BLM) is a chemotherapeutic agent that produces pulmonary
fibrosis. Curcumin is a naturally occurring compound, uses in medicine and has many …

 Pulmonary fibrosis is a chronic, progressive and refractory disease, characterized by
activation of myofibroblast followed by extensive extracellular matrix (ECM) deposition. It …

Background: Pulmonary fibrosis (PF) is a chronic fibrotic lung disease. Lung parenchyma
and architecture is destroyed, compliance is lost, and gas exchange is compromised in this …

Objective: The purpose of this study was to investigate the effect of bone marrow
mesenchymal stem cells (BMSCs) on bleomycin-induced pulmonary fibrosis in mice …

Methods Bone marrow MSC were harvested from 6 week old male SD rats. Forty-eight
female SD rats were randomly divided into six groups. The pulmonary fibrosis models were …

Results: Lung GFP positive populations from BIPF mice consisted of two distinct phenotypes,
GFP low (Glo) and GFP hi (Ghi) populations. Ghi, but not Glo, population was found to be …