ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Much structural information has been amassed on ATP-binding cassette (ABC) transporters,
including hundreds of structures of isolated domains and an increasing array of full-length …

ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that
utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all …

ATP-binding cassette (ABC) transporters are central to many physiological processes,
including the uptake of nutrients, the non-classical secretion of signaling molecules and …

ATP-binding cassette (ABC) transporters are found in all domains of life and constitute one
of the largest protein superfamilies. ABC transporters harness the energy of ATP binding …

ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar
endo‐and xenobiotics in the human body, especially in the tissue barriers and the …

The past decade has seen a remarkable surge in structural characterization of ATP binding
cassette (ABC) transporters, which have spurred a more focused functional analysis of these …

ABC transporters catalyze transport reactions, such as the high-affinity uptake of
micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells …

In this review, we summarize the currently available information on the membrane topology
of some key members of the human ABC protein subfamilies, and present the predicted …