Discovery of potent and selective covalent inhibitors of JNK
The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that
transduce and integrate extracellular stimuli into coordinated cellular response. Here, we …
transduce and integrate extracellular stimuli into coordinated cellular response. Here, we …
Small molecule JNK (c-Jun N-terminal kinase) inhibitors
MA Siddiqui, PA Reddy - Journal of medicinal chemistry, 2010 - ACS Publications
JNKsa (c-jun NH2-terminal kinases) are members of the MAP kinase family1 that are
primarily activated by cytokines and exposure to environmental stress. 2, 3 JNKs are …
primarily activated by cytokines and exposure to environmental stress. 2, 3 JNKs are …
The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
The c-Jun terminal kinases (JNKs) are members of the mitogen-activated protein (MAP)
kinase family and regulate signal transduction in response to environmental stress …
kinase family and regulate signal transduction in response to environmental stress …
Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
YS Heo, SK Kim, CI Seo, YK Kim, BJ Sung… - The EMBO …, 2004 - embopress.org
The c‐jun N‐terminal kinase (JNK) signaling pathway is regulated by JNK‐interacting
protein‐1 (JIP1), which is a scaffolding protein assembling the components of the JNK …
protein‐1 (JIP1), which is a scaffolding protein assembling the components of the JNK …
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
JL Stebbins, SK De, T Machleidt… - Proceedings of the …, 2008 - National Acad Sciences
JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of
disease states. JNK-interacting protein-1 (JIP1) is a scaffolding protein that enhances JNK …
disease states. JNK-interacting protein-1 (JIP1) is a scaffolding protein that enhances JNK …
Targeting JNK for therapeutic benefit: from junk to gold?
AM Manning, RJ Davis - Nature reviews Drug discovery, 2003 - nature.com
The c-Jun NH2-terminal kinases (JNKs) phosphorylate and activate members of the
activator protein-1 (AP-1) transcription factor family and other cellular factors implicated in …
activator protein-1 (AP-1) transcription factor family and other cellular factors implicated in …
Recent progress in the design, study, and development of c-Jun N-terminal kinase inhibitors as anticancer agents
A Messoussi, C Feneyrolles, A Bros, A Deroide… - Chemistry & biology, 2014 - cell.com
The c-Jun N-terminal kinase (JNK) family, with its three members JNK1, JNK2, and JNK3, is
a subfamily of mitogen-activated protein kinases. Involved in many aspects of cellular …
a subfamily of mitogen-activated protein kinases. Involved in many aspects of cellular …
JNK signalling in cancer: in need of new, smarter therapeutic targets
The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential
The c-Jun N-terminal protein kinases (JNKs) form one subfamily of the mitogen-activated
protein kinase (MAPK) group of serine/threonine protein kinases. The JNKs were first …
protein kinase (MAPK) group of serine/threonine protein kinases. The JNKs were first …
c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges
MA Bogoyevitch, KRW Ngoei, TT Zhao… - … et Biophysica Acta (BBA …, 2010 - Elsevier
c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …