Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …
EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives
AAE Mourad, NA Farouk, ESH El-Sayed, ARE Mahdy - Life Sciences, 2021 - Elsevier
Aims EGFR and VEGFR-2 have emerged as promising targets for cancer management as
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
Design, synthesis and anticervical cancer activity of new benzofuran–pyrazol-hydrazono-thiazolidin-4-one hybrids as potential EGFR inhibitors and apoptosis …
HAS Abbas, SS Abd El-Karim - Bioorganic chemistry, 2019 - Elsevier
This study represents the synthetic approaches of a new set of 2-(((3-(benzofuran-2-yl)-1-
phenyl-1H-pyrazol-4-yl) methylene) hydrazono)-5-(aryl) thiazolidin-4-one derivatives 4–22 …
phenyl-1H-pyrazol-4-yl) methylene) hydrazono)-5-(aryl) thiazolidin-4-one derivatives 4–22 …
Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors
Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …
National Cancer Institute evaluated all the newly synthesized compounds for their …
New thiazolidine-2, 4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies
Background VEGFR-2 has emerged as a prominent positive regulator of cancer
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo [3, 4-d] Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell …
A series of novel hybrid pyrazolo [3, 4-d] pyramidine derivatives was designed and
chemically synthesized in useful yields. The synthesized compounds were structurally …
chemically synthesized in useful yields. The synthesized compounds were structurally …
Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies
Novel hybrids of pyridazine-pyrazoline were synthesized aiming to develop new
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …
antiproliferative candidates. All compounds were submitted to the National Cancer Institute …