Deciphering the chemical lexicon of host–gut microbiota interactions

GR Nicolas, PV Chang - Trends in pharmacological sciences, 2019 - cell.com
The human intestine harbors an immense, diverse, and critical population of bacteria that
has effects on numerous aspects of host physiology, immunity, and disease. Emerging …

Deciphering human microbiota–host chemical interactions

JE Silpe, EP Balskus - ACS Central Science, 2020 - ACS Publications
Our gut harbors more microbes than any other body site, and accumulating evidence
suggests that these organisms have a sizable impact on human health. Though efforts to …

Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens

SL Vogt, J Peña-Díaz, BB Finlay - Anaerobe, 2015 - Elsevier
Gastrointestinal pathogens must overcome many obstacles in order to successfully colonize
a host, not the least of which is the presence of the gut microbiota, the trillions of commensal …

Microbial metabolites in health and disease: Navigating the unknown in search of function

KB Martinez, V Leone, EB Chang - Journal of Biological Chemistry, 2017 - ASBMB
The gut microbiota has been implicated in the development of a number of chronic
gastrointestinal and systemic diseases. These include inflammatory bowel diseases, irritable …

[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

Microbial contribution to the human metabolome: implications for health and disease

W Van Treuren, D Dodd - Annual Review of Pathology …, 2020 - annualreviews.org
The human gastrointestinal tract is home to an incredibly dense population of microbes.
These microbes employ unique strategies to capture energy in this largely anaerobic …

Pathways and functions of gut microbiota metabolism impacting host physiology

S Krishnan, N Alden, K Lee - Current opinion in biotechnology, 2015 - Elsevier
Highlights•Intestinal microbiota performs diverse metabolic functions essential for host
physiology.•Small molecule products of microbiota metabolism act as nutrients and …

Effect of antibiotic treatment on the intestinal metabolome

LCM Antunes, J Han, RBR Ferreira… - Antimicrobial agents …, 2011 - Am Soc Microbiol
The importance of the mammalian intestinal microbiota to human health has been intensely
studied over the past few years. It is now clear that the interactions between human hosts …

[HTML][HTML] Understanding the holobiont: how microbial metabolites affect human health and shape the immune system

TS Postler, S Ghosh - Cell metabolism, 2017 - cell.com
The human gastrointestinal tract is populated by a diverse, highly mutualistic microbial flora,
which is known as the microbiome. Disruptions to the microbiome have been shown to be …

Specialized metabolites from the microbiome in health and disease

G Sharon, N Garg, J Debelius, R Knight, PC Dorrestein… - Cell metabolism, 2014 - cell.com
The microbiota, and the genes that comprise its microbiome, play key roles in human health.
Host-microbe interactions affect immunity, metabolism, development, and behavior, and …