Abstract HIV-1-associated neurocognitive disorder (HAND) remains a persistent problem
despite antiretroviral therapy (ART), largely a result of continued inflammation in the …

Background: HIV-1 infection of the CSF space is nearly universal in untreated systemic
infection, and correlates strongly with intrathecal and systemic immunoactivation and CSF …

Objective: Antigen persistence due to HIV is a major source of inflammation and substantial
immune activation, both of which are linked to accelerated aging. This illustrates the need to …

Background: Statins exert pleiotropic anti-inflammatory and immune-modulatory effects,
which might translate into antiviral activity. We evaluated whether reported current statin …

Aims During virally suppressed chronic HIV infection, persistent inflammation contributes to
the development of cardiovascular disease (CVD), a major comorbidity in people living with …

Background Statins have previously been shown to reduce the in vitro infection of human
immunodeficiency virus type 1 (HIV-1) through modulation of Rho GTPase activity and lipid …

HIV infected people are living longer due to the success of combined antiretroviral therapy
(cART). However, greater than 40-70% of HIV infected individuals develop HIV associated …

Recent studies support the notion that statins, widely prescribed cholesterol‐lowering
agents, may target key elements in the immunological cascade leading to inflammation and …

This study characterized immunomodulatory targets of statins in humans and their potential
for treatment of relapsing remitting multiple sclerosis (RR MS). Statins inhibited the …

Immune activation and inflammation are hallmarks of chronic HIV infection and are
etiologically linked to major causes of morbidity and mortality among HIV-infected persons …