Systematic profiling of poly (A)+ transcripts modulated by core 3'end processing and splicing factors reveals regulatory rules of alternative cleavage and …
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing
different 3'untranslated regions (3'UTRs) and/or coding sequences. How core cleavage …
different 3'untranslated regions (3'UTRs) and/or coding sequences. How core cleavage …
Alternative cleavage and polyadenylation: extent, regulation and function
The 3′ end of most protein-coding genes and long non-coding RNAs is cleaved and
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
polyadenylated. Recent discoveries have revealed that a large proportion of these genes …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
developed 3′ region extraction and deep sequencing (3′ READS) to address mispriming …
APAatlas: decoding alternative polyadenylation across human tissues
Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3′ terminus
that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with …
that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with …
Cell-type-specific analysis of alternative polyadenylation using single-cell transcriptomics data
ED Shulman, R Elkon - Nucleic acids research, 2019 - academic.oup.com
Alternative polyadenylation (APA) is emerging as an important layer of gene regulation
because the majority of mammalian protein-coding genes contain multiple polyadenylation …
because the majority of mammalian protein-coding genes contain multiple polyadenylation …
Alternative polyadenylation alters protein dosage by switching between intronic and 3′ UTR sites
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites
P Tang, Y Yang, G Li, L Huang, M Wen… - Nature structural & …, 2022 - nature.com
Analogous to alternative splicing, alternative polyadenylation (APA) has long been thought
to occur independently at proximal and distal polyA sites. Using fractionation-seq, we …
to occur independently at proximal and distal polyA sites. Using fractionation-seq, we …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
Alternative cleavage and polyadenylation: the long and short of it
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …
3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have …