Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
M Kazui, Y Nishiya, T Ishizuka, K Hagihara… - Drug Metabolism and …, 2010 - ASPET
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms
involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically …
involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically …
The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
TA Clarke, LA Waskell - Drug metabolism and disposition, 2003 - ASPET
The prodrug clopidogrel (Plavix) is activated by cytochrome P450 (P450) to a metabolite that
inhibits ADP-induced platelet aggregation. Clopidogrel is frequently administered to patients …
inhibits ADP-induced platelet aggregation. Clopidogrel is frequently administered to patients …
Clopidogrel pathway
After oral administration, clopidogrel is rapidly absorbed. Owing to its extensive metabolism,
clopidogrel is not detected in human plasma. Clopidogrel is a prodrug that is absorbed in …
clopidogrel is not detected in human plasma. Clopidogrel is a prodrug that is absorbed in …
The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance
KA Kim, PW Park, SJ Hong… - Clinical Pharmacology & …, 2008 - Wiley Online Library
We evaluated the effect of the CYP2C19 genotype on the pharmacokinetics and
pharmacodynamcis of clopidogrel. Twenty‐four subjects were divided into three groups on …
pharmacodynamcis of clopidogrel. Twenty‐four subjects were divided into three groups on …
The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects
K Umemura, T Furuta, K Kondo - Journal of Thrombosis and …, 2008 - jthjournal.org
Clopidogrel is a thienopyridine derivative with ADP-antagonistic activity and is widely used
for the prevention of ischemic events in patients who have suffered a stroke, non-ST …
for the prevention of ischemic events in patients who have suffered a stroke, non-ST …
[HTML][HTML] Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
JT Brandt, SL Close, SJ Iturria, CD Payne… - Journal of Thrombosis …, 2007 - Elsevier
Background: Thienopyridines are metabolized to active metabolites that irreversibly inhibit
the platelet P2Y 12 adenosine diphosphate receptor. The pharmacodynamic response to …
the platelet P2Y 12 adenosine diphosphate receptor. The pharmacodynamic response to …
[HTML][HTML] The CYP2C19* 17 variant is not independently associated with clopidogrel response
JP Lewis, SH Stephens, RB Horenstein… - Journal of Thrombosis …, 2013 - Elsevier
Summary Background Cytochrome P450 2C19 (CYP2C19) is the principal enzyme
responsible for converting clopidogrel into its active metabolite, and common genetic …
responsible for converting clopidogrel into its active metabolite, and common genetic …
Cytochrome P450 2C19* 2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis
Several polymorphisms in genes that encode platelet components (receptors or enzymes),
or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been …
or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been …
[HTML][HTML] Cytochrome p-450 polymorphisms and response to clopidogrel
JL Mega, SL Close, SD Wiviott, L Shen… - New England journal …, 2009 - Mass Medical Soc
Background Clopidogrel requires transformation into an active metabolite by cytochrome P-
450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are …
450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are …
Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
DJ Angiolillo, A Fernandez-Ortiz… - … , and vascular biology, 2006 - Am Heart Assoc
Objectives—Metabolic activity of cytochrome P450 (CYP) 3A4 has been associated with
clopidogrel response variability. Because metabolic activity of CYP3A4 is genetically …
clopidogrel response variability. Because metabolic activity of CYP3A4 is genetically …