The formation, maintenance and reorganization of synapses are critical for brain
development and the responses of neuronal circuits to environmental challenges. Here we …

Growth of new dendritic spines contributes to experience-dependent circuit plasticity in the
cerebral cortex. Yet the signaling mechanisms leading to new spine outgrowth remain …

The majority of excitatory synapses in the mammalian brain form on filopodia and spines,
actin-rich membrane protrusions present on neuronal dendrites. The biochemical events …

The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in
ensuring correct synaptogenesis. We show that mitochondrial biogenesis in developing …

The energetic costs of behavioral chronic stress are unlikely to be sustainable without
neuronal plasticity. Mitochondria have the capacity to handle synaptic activity up to a limit …

Use-dependent selection of optimal connections is a key feature of neural circuit
development and, in the mature brain, underlies functional adaptation, such as is required …

Brain-derived neurotrophic factor (BDNF) is a potent modulator of synaptic transmission and
plasticity in the CNS, acting both pre-and postsynaptically. We demonstrated recently that …

Microtubules (MTs) are capable of entering dendritic spines in mature hippocampal neurons
through dynamic polymerization. Although these MT invasions are directly associated with …

The transcriptional coactivator peroxisome proliferator activated receptor γ coactivator 1α
(PGC‐1α) can activate a number of transcription factors to regulate mitochondrial biogenesis …

Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of
Parkinson's disease. Therefore, pathways controlling mitochondrial activity rapidly emerge …