The PI3K-Akt-mTOR and associated signaling pathways as molecular drivers of immune-mediated inflammatory skin diseases: update on therapeutic strategy using …

T Roy, ST Boateng, MB Uddin, S Banang-Mbeumi… - Cells, 2023 - mdpi.com
The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

[HTML][HTML] Recent updates on the involvement of PI3K/AKT/mTOR molecular cascade in the pathogenesis of hyperproliferative skin disorders

L Mercurio, C Albanesi, S Madonna - Frontiers in Medicine, 2021 - frontiersin.org
PhosphoInositide-3 Kinase (PI3K) represents a family of different classes of kinases which
control multiple biological processes in mammalian cells, such as cell growth, proliferation …

Predominant role of mTOR signaling in skin diseases with therapeutic potential

F Karagianni, A Pavlidis, LS Malakou, C Piperi… - International Journal of …, 2022 - mdpi.com
The serine/threonine kinase mechanistic target of rapamycin (mTOR) plays a pivotal role in
the regulation of cell proliferation, survival, and motility in response to availability of energy …

[PDF][PDF] Phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin pathway in psoriasis pathogenesis. A potential therapeutic target?

T Huang, X Lin, X Meng, M Lin - Acta dermato …, 2014 - medicaljournalssweden.se
Psoriasis is a common chronic inflammatory disease of the skin. Its pathogenesis has not
been completely elucidated. Phosphoinositide-3 kinase/protein kinase-B/mammalian target …

Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic agents …

JC Chamcheu, T Roy, MB Uddin, S Banang-Mbeumi… - Cells, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

mTOR signaling cascade in psoriatic disease: double kinase mTOR inhibitor a novel therapeutic target

SK Raychaudhuri… - Indian journal of …, 2014 - journals.lww.com
In this short communication we are providing insight about the regulatory role of the
phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) kinase …

Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease

MS Leo, RK Sivamani - Archives of Dermatological Research, 2014 - Springer
The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth,
proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two …

The PI3K/Akt pathway: emerging roles in skin homeostasis and a group of non-malignant skin disorders

Y Teng, Y Fan, J Ma, W Lu, N Liu, Y Chen, W Pan… - Cells, 2021 - mdpi.com
The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates
cell proliferation, differentiation, and migration, along with angiogenesis and metabolism …

Exploiting PI 3 K/m TOR signaling to accelerate epithelial wound healing

RM Castilho, CH Squarize, JS Gutkind - Oral diseases, 2013 - Wiley Online Library
The molecular circuitries controlling the process of skin wound healing have gained new
significant insights in recent years. This knowledge is built on landmark studies on skin …

Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies

JG Foster, MD Blunt, E Carter, SG Ward - Pharmacological reviews, 2012 - ASPET
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …