Kisspeptin (encoded by Kiss1), a neuropeptide critically involved in neuroendocrine
regulation of reproduction, is primarily synthesized in two hypothalamic nuclei: the …

The brains of males and females differ anatomically and physiologically, including sex
differences in neurone size or number, synapse morphology and specific patterns of gene …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Kisspeptin plays a pivotal role in pubertal onset and reproductive function. In rodents,
kisspeptin perikarya are located in 2 major populations: the anteroventral periventricular …

Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor
(Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models …

Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed
central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

Hypothalamic kisspeptin neurons integrate and translate cues from the internal and external
environments that regulate gonadotropin-releasing hormone (GnRH) secretion and maintain …

Kisspeptin cells appear to be the “missing link,” bridging the divide between levels of
gonadal steroids and feedback control of gonadotropin-releasing hormone (GnRH) …