Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way

OA Chaves, CQ Sacramento… - Journal of Molecular …, 2022 - academic.oup.com
The severe coronavirus disease 2019 (COVID-19) is associated with coagulopathy.
Anticoagulants, such as low-molecular-weight heparin, warfarin, thrombin inhibitors, and …

Safety and efficacy of apixaban for therapeutic anticoagulation in critically ill ICU patients with severe COVID-19 respiratory disease

E Wenzler, MH Engineer, M Yaqoob, ST Benken - TH open, 2020 - thieme-connect.com
Introduction Despite the use of unfractionated heparin (UFH) or low molecular weight
heparin (LMWH), rates of thromboembolic disease, and subsequent morbidity and mortality …

Coagulation system activation for targeting of COVID-19: insights into anticoagulants, vaccine-loaded nanoparticles, and hypercoagulability in COVID-19 vaccines

MS Abdel-Bakky, E Amin, MG Ewees, NI Mahmoud… - Viruses, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as COVID-
19, is currently developing into a rapidly disseminating and an overwhelming worldwide …

[HTML][HTML] Antiviral anticoagulation

ELG Pryzdial, MR Sutherland, BH Lin… - Research and Practice in …, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel envelope virus
that causes coronavirus disease 2019 (COVID‐19). Hallmarks of COVID‐19 are a puzzling …

[HTML][HTML] Mechanisms of COVID-19 thrombosis in an inflammatory environment and new anticoagulant targets

H Liu, T Hu, C Zhang, X Chen, S Zhang… - American journal of …, 2021 - ncbi.nlm.nih.gov
COVID-19 is widely epidemic in the world and poses a great threat to our life. Coagulopathy
is one of the major characteristics in the COVID-19 patients. A growing number of studies …

Safety and efficacy analysis of apixaban compared to heparins in hospitalized non-critically ill COVID-19 patients

D Appiah, NJ Quinn, EG Messing… - Hospital …, 2022 - journals.sagepub.com
Purpose: Heparin-based regimens are recommended for anticoagulation in hospitalized
patients with COVID-19 though a study reported similar mortality with apixaban in critically ill …

Dysfunctional coagulation in COVID-19: from cell to bedside

J Wang, AM Saguner, J An, Y Ning, Y Yan, G Li - Advances in therapy, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin …

The cross-talk between thrombosis and inflammatory storm in acute and long-COVID-19: therapeutic targets and clinical cases

D Acanfora, C Acanfora, MM Ciccone, P Scicchitano… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) commonly complicates
with coagulopathy. A syndrome called Long-COVID-19 is emerging recently in COVID-19 …

COVID‐19‐related coagulopathy: A review of pathophysiology and pharmaceutical management

M Kohansal Vajari, M Shirin… - Cell biology …, 2021 - Wiley Online Library
December 2019 will never be forgotten in the history of medicine when an outbreak of
pneumonia of unknown etiology in Wuhan, China sooner or later prompted the World Health …

Updates on anticoagulation and laboratory tools for therapy monitoring of heparin, vitamin K antagonists and direct oral anticoagulants

O Kumano, K Akatsuchi, J Amiral - Biomedicines, 2021 - mdpi.com
Anticoagulant drugs have been used to prevent and treat thrombosis. However, they are
associated with risk of hemorrhage. Therefore, prior to their clinical use, it is important to …