Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro

G Gunasingam, R He, P Taladriz-Blanco… - Particle and Fibre …, 2024 - Springer
Background During inhalation, airborne particles such as particulate matter≤ 2.5 μm (PM2.
5), can deposit and accumulate on the alveolar epithelial tissue. In vivo studies have shown …

Systemic and vascular effects of circulating diesel exhaust particulate matter

N Bai, SF van Eeden - Inhalation toxicology, 2013 - Taylor & Francis
Objective: Numerous studies have found an association between transiently increased
particulate matter air pollution and acute adverse cardiovascular health effects; however, the …

Theoretical simulation of diesel exhaust particle clearance from the human respiratory tract

R Sturm - Journal of Public Health and Emergency, 2017 - jphe.amegroups.org
Background: Diesel exhaust particles (DEP) deposited in the human respiratory tract are
commonly seized by an innate defense system including a multitude of clearance …

DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression

MW Chao, IP Po, RJ Laumbach, J Koslosky, K Cooper… - Toxicology, 2012 - Elsevier
Inhalation of diesel exhaust particles (DEPs) is associated with pulmonary and
cardiovascular disease. One contributor to pathogenesis is inhaled particles reaching and …

Deposition of diesel exhaust particles in the human lungs: theoretical simulations and experimental data

R Sturm - Journal of Public Health and Emergency, 2017 - jphe.amegroups.org
Background: Based on numerous experimental and epidemiological studies diesel exhaust
particles (DEPs) have been evaluated as serious health hazards, whose uptake by …

Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions

JR Fox, DP Cox, BE Drury, TR Gould… - Air Quality, Atmosphere …, 2015 - Springer
Epidemiologic studies have linked diesel exhaust (DE) to cardiovascular and respiratory
morbidity and mortality, as well as lung cancer. DE composition is known to vary with many …

Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin

MW Chao, J Kozlosky, IP Po, PO Strickland… - Toxicology, 2011 - Elsevier
Whether diesel exhaust particles (DEPs) potentially have a direct effect on capillary
endothelia was examined by following the adherens junction component, vascular …

Retention modeling of diesel exhaust particles in rats and humans

CP Yu, KJ Yoon, YK Chen - Journal of aerosol medicine, 1991 - liebertpub.com
The objective of this study was to predict the lung burden of diesel exhaust particles (DEPs)
from automobile emissions in rats and humans by means of a mathematical model. We …

Composition of diesel particles influences acute pulmonary toxicity: an experimental study in mice

D Laks, R de Oliveira, P de André… - Inhalation …, 2008 - Taylor & Francis
Ambient particles have been consistently associated with adverse health effects, yielding
mainly high cardiorespiratory morbidity and mortality. Diesel engines represent a major …

Cellular response to diesel exhaust particles strongly depends on the exposure method

AL Holder, D Lucas, R Goth-Goldstein… - Toxicological …, 2008 - academic.oup.com
In vitro exposure to aerosols at the air–liquid interface (ALI) preserves the physical and
chemical characteristics of aerosol particles. Although frequently described as being a more …