The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

The aspartyl protease renin is the rate limiting activity of the renin–angiotensin–aldosterone
system (RAAS). Renin is synthesized as an enzymatically inactive proenzyme which is …

The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone
system, which is critically involved in salt, volume, and blood pressure homeostasis of the …

Since the reviews of this subject by Gross et al.(180) in 1965 and Vander (373) in 1967,
many experiments have been conducted on the control mechanisms for renin release and …

Renin is a central hormone in the control of blood pressure and various other physiological
functions. In spite of the very early discovery of renin over 100 years ago, we have only …

The existence of a tissue renin–angiotensin (RAS) system independent of the circulating
RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

In the adult organism, systemically circulating renin almost exclusively originates from the
juxtaglomerular cells in the afferent arterioles of the kidneys. These cells share similarities …

The renin content of the ischemic kidney of dogs with experimental renal hypertension due
to constriction of only one main renal artery was significantly elevated, while that of the …

A comprehensive review of physiological and molecular biological evidence refutes claims
for synthesis of renin by cardiac and vascular tissues. Cardiovascular tissue renin …