Atherosclerosis is a leading cause of morbidity and mortality in the western world. The
deposition of lipoprotein cholesterol in the arterial wall is a critical early step in the …

Liver X receptors (LXRs) are ligand-dependent transcription factors that are activated by
metabolites of cholesterol, oxysterols, and a number of synthetic agonists. LXRs play potent …

Atherosclerosis is a disease characterized by excess cholesterol and inflammation in the
blood vessels. The liver X receptors (alpha and beta) are members of the nuclear hormone …

Background—The nuclear liver X receptor-α (LXR-α) has been implicated in the regulation
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …

Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters …

Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key
regulators of lipid metabolism and transport but also suppress inflammatory signaling in …

The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

A critical event in the development of atherosclerosis is the recruitment of macrophages to
the underlying epithelial layer of blood vessel walls and the uncontrolled uptake of …

Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent
transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and …

The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor family of
transcription factors that play essential roles in the transcriptional control of lipid metabolism …