The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically,
however most mouse models of the disease harbor pathogenic mutations, rendering them …

A major obstacle in Alzheimer's disease (AD) research is the lack of predictive and
translatable animal models that reflect disease progression and drug efficacy. Transgenic …

Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Background Alzheimer's disease (AD) is a devastating neurodegenerative disorder that
affects a large and growing number of elderly individuals. In addition to idiopathic disease …

Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided
important new information about the pathogenesis of Alzheimer's disease (AD) …

Amyloid β-peptide (Aβ) accumulation is a key characteristic of Alzheimer's disease (AD);
therefore, mouse models of AD exhibiting Aβ pathology are valuable tools for unraveling …

Although, a number of pathogenic mutations have been found for Alzheimer's disease (AD),
only one protective mutation has been identified so far in humans. Here we identify possible …

Background Alzheimer's disease (AD), the most common cause of dementia, is
characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary …

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and
widespread cortical neuronal loss. The “amyloid cascade hypothesis” posits that cerebral …

One of the central research questions on the etiology of Alzheimer's disease (AD) is the
elucidation of the molecular signatures triggered by the amyloid cascade of pathological …