Targeting mechanisms of tailed bacteriophages

FL Nobrega, M Vlot, PA De Jonge… - Nature Reviews …, 2018 - nature.com
Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range

J Taslem Mourosi, A Awe, W Guo, H Batra… - International Journal of …, 2022 - mdpi.com
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …

Long noncontractile tail machines of bacteriophages

AR Davidson, L Cardarelli, LG Pell, DR Radford… - Viral molecular …, 2012 - Springer
In this chapter, we describe the structure, assembly, function, and evolution of the long,
noncontractile tail of the siphophages, which comprise∼ 60% of the phages on earth. We …

Phage–host interplay: examples from tailed phages and Gram-negative bacterial pathogens

S Chaturongakul, P Ounjai - Frontiers in microbiology, 2014 - frontiersin.org
Complex interactions between bacteriophages and their bacterial hosts play significant roles
in shaping the structure of environmental microbial communities, not only by genetic …

Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber

MZ Islam, A Fokine, M Mahalingam, Z Zhang… - Plos …, 2019 - journals.plos.org
Tailed bacteriophages (phages) are one of the most abundant life forms on Earth. They
encode highly efficient molecular machines to infect bacteria, but the initial interactions …

Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1‐specific phages

K Stummeyer, D Schwarzer, H Claus… - Molecular …, 2006 - Wiley Online Library
Bacterial capsules are not only important virulence factors, but also provide attachment sites
for bacteriophages that possess capsule degrading enzymes as tailspike proteins. To gain …

A common evolutionary origin for tailed-bacteriophage functional modules and bacterial machineries

D Veesler, C Cambillau - Microbiology and Molecular Biology …, 2011 - Am Soc Microbiol
Bacteriophages belonging to the order Caudovirales possess a tail acting as a molecular
nanomachine used during infection to recognize the host cell wall, attach to it, pierce it, and …

Structure, function and assembly of the long, flexible tail of siphophages

R Linares, CA Arnaud, S Degroux, G Schoehn… - Current Opinion in …, 2020 - Elsevier
Highlights•Siphophage tails share a common core architecture despite great sequence
diversity.•Myophage tails and phage-related injection systems also share the same …

Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation

R Linares, CA Arnaud, G Effantin, C Darnault… - Science …, 2023 - science.org
Most bacteriophages present a tail allowing host recognition, cell wall perforation, and viral
DNA channeling from the capsid to the infected bacterium cytoplasm. The majority of tailed …