Prognostic gene expression profiling in cutaneous melanoma: identifying the knowledge gaps and assessing the clinical benefit

D Grossman, N Okwundu, EK Bartlett… - JAMA …, 2020 - jamanetwork.com
Importance Use of prognostic gene expression profile (GEP) testing in cutaneous melanoma
(CM) is rising despite a lack of endorsement as standard of care. Objective To develop …

Expert consensus on the use of prognostic gene expression profiling tests for the management of cutaneous melanoma: consensus from the skin cancer prevention …

AS Farberg, JW Marson, A Glazer, GH Litchman… - Dermatology and …, 2022 - Springer
Background Prognostic assessment of cutaneous melanoma relies on historical,
clinicopathological, and phenotypic risk factors according to American Joint Committee on …

Performance of gene expression profile tests for prognosis in patients with localized cutaneous melanoma: a systematic review and meta-analysis

MA Marchetti, DG Coit, SW Dusza, A Yu… - JAMA …, 2020 - jamanetwork.com
Importance The performance of prognostic gene expression profile (GEP) tests for
cutaneous melanoma is poorly characterized. Objective To systematically assess the …

Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice

D Grossman, CC Kim, RI Hartman, E Berry… - Melanoma …, 2019 - Taylor & Francis
Prognostic gene expression profiling (GEP) tests for cutaneous melanoma (CM) are not
recommended in current guidelines outside of a clinical trial. However, their use is becoming …

Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

EC Hsueh, JR DeBloom, J Lee, JJ Sussman… - Journal of hematology & …, 2017 - Springer
Background A 31-gene expression profile (GEP) test that provides risk classification of
cutaneous melanoma (CM) patients has been validated in several retrospective studies. The …

Impact of gene expression profiling on decision-making in clinically node negative melanoma patients after surgical staging.

D Schuitevoerder, M Heath, RW Cook… - Journal of drugs in …, 2018 - europepmc.org
The surgeon's role in the follow-up of pathologic stage I and II melanoma patients has
traditionally been minimal. Melanoma genetic expression profile (GEP) testing provides …

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

JS Zager, BR Gastman, S Leachman, RC Gonzalez… - BMC cancer, 2018 - Springer
Background The heterogeneous behavior of patients with melanoma makes prognostication
challenging. To address this, a gene expression profile (GEP) test to predict metastatic risk …

Estimation of prognosis in invasive cutaneous melanoma: an independent study of the accuracy of a gene expression profile test

BN Greenhaw, JA Zitelli, DG Brodland - Dermatologic Surgery, 2018 - journals.lww.com
BACKGROUND Cutaneous melanomas (CMs) with similar clinical and histopathologic
features can harbor differing capacities for metastasis. A validated gene expression profile …

Prospective validation of the prognostic 31‐gene expression profiling test in primary cutaneous melanoma

J Keller, TL Schwartz, JM Lizalek, E Chang… - Cancer …, 2019 - Wiley Online Library
Background Gene expression profiling (GEP) has been integrated into cancer treatment
decision‐making in multiple neoplasms. We prospectively evaluated the prognostic utility of …

[HTML][HTML] Prospective, multicenter clinical impact evaluation of a 31-gene expression profile test for management of melanoma patients

LD Dillon, JE Gadzia, RS Davidson… - SKIN The Journal of …, 2018 - jofskin.org
Objective: A 31-gene expression profile (GEP) test that has been clinically validated
identifies melanoma patients with low (Class 1) or high (Class 2) risk of metastasis based on …