Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Aberrant glycosylation, a common feature associated with malignancy, has been implicated
in important events during cancer progression. Our understanding of the role of glycans in …

The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of
immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs …

The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …

A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

Virtually all cells and extracellular material are heavily decorated by various glycans, yet our
understanding of the structure and function of these moieties lags behind the understanding …

The immune system must be tightly held in check to avoid bystander tissue damage as well
as autoreactivity caused by overwhelming immune reactions. A novel family of …

Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

The immune system is a complex functional network of diverse cells and soluble molecules
orchestrating innate and adaptive immunity. Biological information, to run these intricate …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …