Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave
survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

Background Little is known about the roles of myeloid cell subsets in kidney injury and in the
limited ability of the organ to repair itself. Characterizing these cells based only on surface …

Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on
damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI …

Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the
underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely …

Incomplete repair after acute kidney injury can lead to development of chronic kidney
disease. To define the mechanism of this response, we compared mice subjected to …

Homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-
induced acute kidney injury (AKI) are poorly understood. Here, we performed single-cell …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …