Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …

Acute inflammation plays an important role in the pathogenic progression of post-ischemic
neuronal damage. Apelin-13 has been investigated as a neuropeptide for various …

Background Neuroinflammation and oxidative stress play important roles in early brain
injury following subarachnoid hemorrhage (SAH). This study is the first to show that …

Alzheimer's disease (AD) by progressive neurodegenerative pattern is associated with
autophagy stress which is suggested as a potential cause of amyloid β (Aβ) aggregation and …

The adipocytokine apelin is a peptide, Apelin and its receptor are abundantly expressed in
the nervous and cardiovascular systems. Previous studies had found apelin-13 reduces …

Apelin has been proved to protect the heart against ischemia/reperfusion (I/R) injury via the
activation of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated …

Background Previous studies had showed that Apelin 13 could protect against apoptosis
induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 …

Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled
receptor, and it may be neuroprotective against cerebral ischemia injury. However, the …

Apelin has been proved to be protective against apoptosis induced by ischemic reperfusion.
However, mechanisms whereby apelin produces neuroprotection remain to be elucidated …

Localization of apelin and its receptor APJ in limbic structures such as the hippocampus
suggests potential involvement of apelin/APJ signaling in stress-related emotional …