Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality
B Demarco, JP Grayczyk, E Bjanes, D Le Roy… - Science …, 2020 - science.org
Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
E Bjanes, RG Sillas, R Matsuda, B Demarco… - PLoS …, 2021 - journals.plos.org
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory
caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates …
caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates …
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling
Injection of effector proteins to block host innate immune signaling is a common strategy
used by many pathogenic organisms to establish an infection. For example, pathogenic …
used by many pathogenic organisms to establish an infection. For example, pathogenic …
Pyroptosis: gasdermin-mediated programmed necrotic cell death
Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …
Gasdermins: making pores for pyroptosis
F Shao - Nature Reviews Immunology, 2021 - nature.com
Journal Club Journal Club Journal Club Page 1 www.nature.com/nri 0123456789();: ReseaRch
highlights 620 | oCToBeR 2021 | voLuMe 21 Pathogeninduced inflammation manifests as an …
highlights 620 | oCToBeR 2021 | voLuMe 21 Pathogeninduced inflammation manifests as an …
Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions
RA Aglietti, EC Dueber - Trends in immunology, 2017 - cell.com
Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …
The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia
INTRODUCTION An inflammatory innate immune response is a first line of host defense
against invading pathogens. Inflammation recruits immune cells to the infection site and …
against invading pathogens. Inflammation recruits immune cells to the infection site and …
[PDF][PDF] Neutrophil caspase-11 is essential to defend against a cytosol-invasive bacterium
Summary Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis,
eliminating intracellular replication niches. We previously showed that macrophages detect …
eliminating intracellular replication niches. We previously showed that macrophages detect …
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