With the elucidation of the human genome sequence over the past decade,
pharmacogenetics has evolved into an important area of translational medicine research …

Pharmacogenetics (or pharmacogenomics) studies the role of inherited and acquired
genetic variation in drug response. Clinically relevant pharmacogenetic examples, mainly …

The field of cytochrome P450 pharmacogenetics has progressed rapidly during the past 25
years. All the major human drug-metabolizing P450 enzymes have been identified and …

Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to
the potential for clinically recognizable interactions between a set of old polymorphic genes …

Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of
many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been shown to be …

The cytochromes P450s can be divided in two groups, those of high importance for
endogenous functions being evolutionary quite stable and those participating in …

No one should debate the importance of cytochrome P450 3A to inter-individual differences
in the pharmacokinetics of drugs. The enzyme is prominent in the liver1 and GI tract, 2 is …

Important interindividual differences in drug pharmacokinetics cause absence of drug
response or adverse drug reactions in significant fractions of the populations. The …

The risk of drug dependence is determined by the interaction of drug, individual and
environment.'Pharmacogenetics' is the study of the influence of heredity on the response to …

Genetic variation in drug metabolizing enzymes is an important contributor to interindividual
variation in drug disposition and response and is associated with significant clinical …