Efficacy and safety of colesevelam for the treatment of bile acid diarrhoea: a double-blind, randomised, placebo-controlled, phase 4 clinical trial

C Borup, L Vinter-Jensen, SPG Jørgensen… - The Lancet …, 2023 - thelancet.com
Background Bile acid diarrhoea is a common but overlooked cause of chronic watery
diarrhoea. Plasma 7α-hydroxy-4-cholesten-3-one (C4) is an alternative to the gold standard …

Prospective comparison of diagnostic tests for bile acid diarrhoea

C Borup, L Vinter‐Jensen… - Alimentary …, 2024 - Wiley Online Library
Background Bile acid diarrhoea is often missed because gold standard nuclear medicine
tauroselcholic [75‐Se] acid (SeHCAT) testing has limited availability. Empirical treatment …

Managing bile acid diarrhoea

JRF Walters, SS Pattni - Therapeutic advances in …, 2010 - journals.sagepub.com
Bowel symptoms including diarrhoea can be produced when excess bile acids (BA) are
present in the colon. This condition, known as bile acid or bile salt malabsorption, has been …

bile acid diarrhoea–pathogenesis, diagnosis and management

N Mottacki, M Simrén, A Bajor - Alimentary pharmacology & …, 2016 - Wiley Online Library
Background Bile acid diarrhoea results from imbalances in the homoeostasis of bile acids in
the enterohepatic circulation. It can be a consequence of ileal disease/dysfunction …

[HTML][HTML] The impact of treatment with bile acid sequestrants on quality of life in patients with bile acid diarrhoea

A Kumar, N Galbraith, HO Al-Hassi, M Jain… - BMC …, 2022 - Springer
Background Bile acid diarrhoea (BAD) can be severely debilitating and negatively affect
patients' quality of life (QoL). We carried out a multi-centre prospective study exploring QoL …

Systematic review: the management of chronic diarrhoea due to bile acid malabsorption

C Wilcox, J Turner, J Green - Alimentary pharmacology & …, 2014 - Wiley Online Library
Background Bile acid malabsorption (BAM) is a common, yet under‐recognised, cause of
chronic diarrhoea, with limited guidance available on the appropriate management of …

Colesevelam for the treatment of bile acid malabsorption-associated diarrhea in patients with Crohn's disease: a randomized, double-blind, placebo-controlled study

F Beigel, N Teich, S Howaldt, F Lammert… - Journal of Crohn's …, 2014 - academic.oup.com
Abstract Background and Aims: Bile acid malabsorption (BAM)-associated diarrhea is an
important clinical issue in patients with Crohn's disease (CD). We analyzed the efficacy and …

Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: a retrospective chart review and patient questionnaire

L Wedlake, K Thomas, A Lalji, C Anagnostopoulos… - Clinical …, 2009 - Elsevier
Background: Commercially available bile-acid sequestrants are not well tolerated by> 80%
of patients. Objective: The aim of the present study was to assess the effectiveness and …

Diagnosis and management of bile acid diarrhoea: a survey of UK expert opinion and practice

JRF Walters, R Arasaradnam, HJN Andreyev - Frontline …, 2020 - fg.bmj.com
Objective Bile acid diarrhoea (BAD), which includes bile acid malabsorption, causes a
variety of digestive symptoms. Diagnostic rates and management vary considerably. We …

Effects of colesevelam on bowel symptoms, biomarkers, and colonic mucosal gene expression in patients with bile acid diarrhea in a randomized trial

P Vijayvargiya, M Camilleri, P Carlson, A Nair… - Clinical …, 2020 - Elsevier
Background & Aims Approximately one-third of patients with IBS-diarrhea (IBS-D) have
increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of …