Objectives To determine the existence of concentration–toxicity relationships for common β-
lactam antibiotic adverse effects and define thresholds above which toxicity is more likely …

Beta-lactams remain a critical member of our antibiotic armamentarium and are among the
most commonly prescribed antibiotic classes in the inpatient setting. For these agents, the …

Traditional antibiotic dosing was not designed for today's escalating antibiotic resistance,
lack of novel antibiotics and growing complexity in patient populations. Dosing that ensures …

Beta-lactams are the most commonly prescribed antimicrobials in intensive care unit (ICU)
settings and remain one of the safest antimicrobials prescribed. However, the misdiagnosis …

Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Introduction: β-lactams have been consistently associated with the majority of drug-related
adverse events. Generally, these are mild under proper dosing and judicious selection …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

The most important pharmacodynamic parameter for β-lactam antibiotics has been shown to
be the time above the MIC, which is used as an argument to administer β-lactam antibiotics …

The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …

OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …