Riboflavin-targeted drug delivery
M Darguzyte, N Drude, T Lammers, F Kiessling - Cancers, 2020 - mdpi.com
Active targeting can improve the retention of drugs and drug delivery systems in tumors,
thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are …
thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are …
Evaluation of riboflavin transporters as targets for drug delivery and theranostics
L Bartmann, D Schumacher, S Von Stillfried… - Frontiers in …, 2019 - frontiersin.org
The retention and cellular internalization of drug delivery systems and theranostics for
cancer therapy can be improved by targeting molecules. Since an increased uptake of …
cancer therapy can be improved by targeting molecules. Since an increased uptake of …
Balancing passive and active targeting to different tumor compartments using riboflavin-functionalized polymeric nanocarriers
Y Tsvetkova, N Beztsinna, M Baues, D Klein, A Rix… - Nano …, 2017 - ACS Publications
Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly
upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes …
upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes …
Influence of riboflavin targeting on tumor accumulation and internalization of Peptostar based drug delivery systems
M Darguzyte, R Holm, J Baier, N Drude… - Bioconjugate …, 2020 - ACS Publications
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to
be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using …
be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using …
Amphiphilic phospholipid-based riboflavin derivatives for tumor targeting nanomedicines
N Beztsinna, Y Tsvetkova, M Bartneck… - Bioconjugate …, 2016 - ACS Publications
Riboflavin (RF) is an essential vitamin for cellular metabolism. Recent studies have shown
that RF is internalized through RF transporters, which are highly overexpressed by prostate …
that RF is internalized through RF transporters, which are highly overexpressed by prostate …
Riboflavin-targeted polymer conjugates for breast tumor delivery
LM Bareford, BR Avaritt, H Ghandehari, A Nan… - Pharmaceutical …, 2013 - Springer
Purpose In breast cancer, a significant decrease in riboflavin (RF) serum levels and increase
in RF carrier protein occurs, indicating a potential role of RF in disease progression. To …
in RF carrier protein occurs, indicating a potential role of RF in disease progression. To …
Bioengineered riboflavin in nanotechnology
N Beztsinna, M Solé, N Taib, I Bestel - Biomaterials, 2016 - Elsevier
Riboflavin (RF) is an essential water-soluble vitamin with unique biological and
physicochemical properties such as transporterspecific cell internalization, implication in …
physicochemical properties such as transporterspecific cell internalization, implication in …
Vitamin B12-Mediated Transport: A Potential Tool for Tumor Targeting of Antineoplastic Drugs and Imaging Agents
Y Gupta, DV Kohli, SK Jain - Critical Reviews™ in Therapeutic …, 2008 - dl.begellhouse.com
The uptake of vitamin B 12 (cyanocobalamin, Cbl/VB12) in mammalian cells is mediated by
specific, high-affinity receptors for the vitamin B 12-binding protein, transcobalamin II, which …
specific, high-affinity receptors for the vitamin B 12-binding protein, transcobalamin II, which …
In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts
J Jayapaul, S Arns, M Bunker, M Weiler, S Rutherford… - Nano Research, 2016 - Springer
Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (eg flavin
mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways …
mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways …
A novel rhodamine− riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization …
Riboflavin (vitamin B2, RF) is taken up in eukaryotic cells via specialized transport
mechanisms. Although RF has fluorescence properties, direct microscopic visualization of …
mechanisms. Although RF has fluorescence properties, direct microscopic visualization of …