Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate
mitophagy and improve muscle health in old animals and in preclinical models of aging …

Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a
strategy to mitigate muscle decline. We present results from a randomized, placebo …

Importance Aging is associated with a decline in mitochondrial function and reduced
exercise capacity. Urolithin A is a natural gut microbiome–derived food metabolite that has …

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …

Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy.
According to the World Health Organization, OA affects over 500 million people and is …

Urolithins are the gut metabolites produced from ellagitannin‐rich foods such as
pomegranates, tea, walnuts, as well as strawberries, raspberries, blackberries, and …

Abstract Background Urolithin A (UA) is produced by gut microflora from foods rich in
ellagitannins. UA has been shown to improve mitochondrial health preclinically and in …

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite
advances in genetic and pharmacological disease-modifying treatments, its management …

Objective Urolithin A (UroA) is a major metabolite of ellagic acid produced following
microbial catabolism in the gut. Emerging evidence has suggested that UroA modulates …

In the present study, we investigated the effects of urolithin A (UA), a metabolite generated
from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential …