Cancer is frequently associated with activation of blood coagulation, which in turn has been
suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin …

Activated protein C (APC) is best known as a natural anticoagulant that also has direct cell
signaling properties which (among others) enhance vascular barrier function. We recently …

Activated protein C (APC) and protein C inhibitor (PCI) are the major components of the
anticoagulant protein C pathway. Recently, APC and PCI have been demonstrated to play …

Introduction Procoagulant factors promote cancer progression and metastasis. Protein C is
involved in hemostasis, inflammation and signal transduction, and has a protective effect on …

The hemostatic system plays pleiotropic roles in cancer progression by shaping the tumor
microenvironment and metastatic niches through thrombin-dependent fibrin deposition and …

Engagement of endothelial protein C receptor (EPCR) by activated protein C (aPC)
decreases expression of endothelial adhesion molecules implicated in tumor-endothelium …

Activated protein C (APC), an anticoagulant serine protease, has been shown to have non-
hemostatic functions related to inflammation, cell survival, and cell migration. In this study we …

Activated protein C (APC) is a serine protease that regulates thrombin (IIa) production
through inactivation of blood coagulation factors Va and VIIIa. APC also has non-hemostatic …

Abstract Introduction Protein C inhibitor (PCI), a member of the serine protease inhibitor
family, is expressed in various human tissues, including liver and kidneys. In the plasma …

Activated protein C (APC) has both anticoagulant activity and direct cell-signaling properties.
APC has been reported to promote cancer cell migration/invasion and to inhibit apoptosis …