Background Gene-environment interaction contributes to the risks of psychiatric disorders.
Interactions between FKBP5 gene variants and early-life stress may enhance the risk not …

Objective: The binding protein FKBP5 is an important modulator of the function of the
glucocorticoid receptor, the main receptor of the stress hormone system. This turns the …

Previous studies have investigated the association between common variants in FKBP5 and
MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta …

FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid
receptor. Polymorphisms at the FKBP5 locus have been associated with increased …

Context Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-
chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an …

Background Twin studies have demonstrated that both genetic and environmental factors
influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …

Context In addition to trauma exposure, other factors contribute to risk for development of
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors …

Mood and anxiety disorders are considered stress‐related diseases characterized by an
impaired function of mineralocorticoid and glucocorticoid receptors (MR and GR …

Despite increased attention to global mental health, psychiatric genetic research has been
dominated by studies in high-income countries, especially with populations of European …

BACKGROUND: Genetic variations in FKBP5, BDNF, P2RX7 and CACNA1 are current
candidates for involvement in depression. METHODS: The single nucleotide polymorphisms …