Impact sur la relation hôte-pathogène de l'interaction entre l'hélicase UPF1 et les transporteurs rétroviraux, Rex d'HTLV-1 et Rev d'HIV-1
L Prochasson - 2022 - theses.hal.science
De par son rôle central dans plusieurs voies de dégradation de l'ARN, l'hélicase UPF1 (UP-
Frameshift 1) est associée à différents processus cellulaires contrôlant la stabilité de l'ARN …
Frameshift 1) est associée à différents processus cellulaires contrôlant la stabilité de l'ARN …
HTLV-1 Rex hijacks UPF1 in a CRM1 dependent manner, leading to NMD inhibition and revealing unexpected proviral roles of UPF1
L Prochasson, M Mghezzi-Habellah, A Roisin, M Palma… - bioRxiv, 2023 - biorxiv.org
The hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we
investigated the consequences of this hijacking for the host. During HTLV-1 infection, we …
investigated the consequences of this hijacking for the host. During HTLV-1 infection, we …
[HTML][HTML] Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import
L Gu, T Tsuji, MA Jarboui, GP Yeo, N Sheehy, WW Hall… - Retrovirology, 2011 - Springer
Background The HIV-1 regulatory protein Rev, which is essential for viral replication,
mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires …
mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires …
[HTML][HTML] HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition
F Fiorini, JP Robin, J Kanaan, M Borowiak… - Nature …, 2018 - nature.com
Abstract Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-
mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here …
mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here …
Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-β
BR Henderson, P Percipalle - Journal of molecular biology, 1997 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) Rev protein binds to unspliced HIV-1 pre-
mRNA and exports it from the nucleus. Rev itself can “shuttle” between the nucleus and …
mRNA and exports it from the nucleus. Rev itself can “shuttle” between the nucleus and …
A Trans-Dominant Negative HIV Type 1 Rev with Intact Domains of NLS/NOS and NES
J Fang, S Kubota, RJ Pomerantz - AIDS research and human …, 2002 - liebertpub.com
The nuclear diffusion inhibitory signal (NIS) is a 15-amino acid peptide motif (10-24;
EDLLKAVRLIKFLYQ) in the N-terminus of the HIV-1 Rev protein. NIS appears to be involved …
EDLLKAVRLIKFLYQ) in the N-terminus of the HIV-1 Rev protein. NIS appears to be involved …
Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev
AS Zolotukhin, BK Felber - Journal of virology, 1999 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) Rev contains a leucine-rich nuclear export
signal that is essential for its nucleocytoplasmic export mediated by hCRM1. We examined …
signal that is essential for its nucleocytoplasmic export mediated by hCRM1. We examined …
[HTML][HTML] Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors
A Kiss, L Li, T Gettemeier, LK Venkatesh - Virology, 2003 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export of viral RNAs
involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear …
involves the interaction of its leucine-rich nuclear export sequence (NES) with nuclear …
Cellular proteins and HIV-1 Rev function
M Suhasini, TR Reddy - Current HIV research, 2009 - ingentaconnect.com
The human immunodeficiency virus (HIV-1) differentially controls viral protein expression at
the level of splicing as well as nuclear export of incompletely spliced viral RNA. This …
the level of splicing as well as nuclear export of incompletely spliced viral RNA. This …
[HTML][HTML] A nucleolar localizing Rev binding element inhibits HIV replication
A Michienzi, FG De Angelis, I Bozzoni… - AIDS research and …, 2006 - Springer
The Rev protein of the human immunodeficiency virus (HIV) facilitates the nuclear export of
intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through …
intron containing viral mRNAs allowing formation of infectious virions. Rev traffics through …