MiR-33 contributes to the regulation of cholesterol homeostasis
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33,
an intronic microRNA (miRNA) located within the gene encoding sterol-regulatory element …
an intronic microRNA (miRNA) located within the gene encoding sterol-regulatory element …
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
SH Najafi-Shoushtari, F Kristo, Y Li, T Shioda… - Science, 2010 - science.org
Proper coordination of cholesterol biosynthesis and trafficking is essential to human health.
The sterol regulatory element–binding proteins (SREBPs) are key transcription regulators of …
The sterol regulatory element–binding proteins (SREBPs) are key transcription regulators of …
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
KJ Rayner, CC Esau, FN Hussain, AL McDaniel… - Nature, 2011 - nature.com
Cardiovascular disease remains the leading cause of mortality in westernized countries,
despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL) …
despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL) …
[HTML][HTML] Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
KJ Rayner, FJ Sheedy, CC Esau… - The Journal of …, 2011 - Am Soc Clin Investig
Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise
HDL levels have remained elusive. Recent advances in the understanding of lipid …
HDL levels have remained elusive. Recent advances in the understanding of lipid …
MicroRNAs in metabolism and metabolic diseases
V Rottiers, SH Najafi-Shoushtari… - Cold Spring Harbor …, 2011 - symposium.cshlp.org
Aberrant cholesterol/lipid homeostasis is linked to a number of diseases prevalent in the
developed world, including metabolic syndrome, type II diabetes, and cardiovascular …
developed world, including metabolic syndrome, type II diabetes, and cardiovascular …
miR-33 links SREBP-2 induction to repression of sterol transporters
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR)
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Cellular imbalances of cholesterol and fatty acid metabolism result in pathological
processes, including atherosclerosis and metabolic syndrome. Recent work from our group …
processes, including atherosclerosis and metabolic syndrome. Recent work from our group …
microRNAs and cholesterol metabolism
Cholesterol metabolism is tightly regulated at the cellular level. In addition to classic
transcriptional regulation of cholesterol metabolism (eg by SREBP and LXR), members of a …
transcriptional regulation of cholesterol metabolism (eg by SREBP and LXR), members of a …
MicroRNA modulation of cholesterol homeostasis
C Fernández-Hernando, KJ Moore - … , thrombosis, and vascular …, 2011 - Am Heart Assoc
Although the roles of the sterol response element binding protein-1 (SREBP1) and SREBP2
transcription factors in regulating fatty acid and cholesterol synthesis and uptake have been …
transcription factors in regulating fatty acid and cholesterol synthesis and uptake have been …
[HTML][HTML] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
T Horie, T Nishino, O Baba, Y Kuwabara… - Nature …, 2013 - nature.com
MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and
inhibit translation or promote mRNA degradation. Recent reports have indicated that miR …
inhibit translation or promote mRNA degradation. Recent reports have indicated that miR …