Organoids and organs-on-a-chip are currently the two major families of 3D advanced
organotypic in vitro culture systems, aimed at reconstituting miniaturized models of …

Human development and disease are challenging to study because of lack of experimental
accessibility to in vivo systems and the complex nature of biological processes. For these …

Medicine today faces the combined challenge of an increasing number of untreatable
diseases and fewer drugs reaching the clinic. While pharmaceutical companies have …

The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …

Frontiers | Corrigendum: 3D organ-on-a-chip: the convergence of microphysiological
systems and organoids Skip to main content Download Article Download Article Download …

Organoids and organ-on-a-chip devices fall under the umbrella of microphysiological
systems (MPS), which, in general, can be defined as miniature cell cultures—usually three …

ABSTRACT From October 12-15th, 2016, EMBO∣ EMBL held a symposium to bring
together those in the scientific community with a shared interest in using three-dimensional …

Abstract Purpose of Review The modeling of biological processes in vitro provides an
important tool to better understand mechanisms of development and disease, allowing for …

While two-dimensional (2D) cell models and animal models have played central roles in
advancing knowledge and understanding of cell biology, neither can accurately recapitulate …

The first concepts for reproducing human systemic organismal biology in vitro were
developed over 12 years ago. Such concepts, then called human-or body-on-a-chip …