Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Integrin signaling is bidirectional.'Inside-out'signals regulate integrin affinity for adhesive
ligands, and ligand-dependent 'outside-in'signals regulate cellular responses to adhesion …

Integrins receive signals from other receptors that lead to activation of ligand binding (inside-
out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular …

Integrins are cell surface adhesion receptors that are essential for the development and
function of multicellular animals. Here we summarize recent findings on the regulation of …

Integrin cell-adhesion receptors mediate interactions between cells and the extracellular
matrix. Dynamic regulation of integrin adhesive function is termedactivation'orinside …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of
metazoans and is important in many diseases. Integrin adhesion receptors can rapidly …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Integrins are cell adhesion receptors that communicate biochemical and mechanical signals
in a bidirectional manner across the plasma membrane and thus influence most cellular …