[HTML][HTML] CC-486 maintenance after stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndromes

M De Lima, B Oran, RE Champlin… - Biology of Blood and …, 2018 - Elsevier
Relapse is the main cause of treatment failure after allogeneic stem cell transplant (alloSCT)
in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable …

[HTML][HTML] Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia

C Craddock, M Labopin, M Robin, J Finke… - …, 2016 - ncbi.nlm.nih.gov
Disease relapse is the most common cause of treatment failure after allogeneic stem cell
transplantation for acute myeloid leukemia and myelodysplastic syndromes, yet treatment …

Maintenance therapy with low‐dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic …

M De Lima, S Giralt, PF Thall, L de Padua Silva… - Cancer, 2010 - Wiley Online Library
BACKGROUND: Recurrence is a major cause of treatment failure after allogeneic
transplantation for acute myelogenous leukemia (AML) and myelodysplastic syndrome …

A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients

B Oran, M de Lima, G Garcia-Manero, PF Thall… - Blood …, 2020 - ashpublications.org
This study investigated the efficacy and safety of azacitidine maintenance in the
posttransplant setting based on the encouraging phase 1/2 reports for azacitidine …

Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes

G Garcia-Manero, SD Gore, S Kambhampati, B Scott… - Leukemia, 2016 - nature.com
CC-486, the oral formulation of azacitidine (AZA), is an epigenetic modifier and DNA
methyltransferase inhibitor in clinical development for treatment of hematologic …

[HTML][HTML] Tolerability and clinical activity of post-transplantation azacitidine in patients allografted for acute myeloid leukemia treated on the RICAZA trial

C Craddock, N Jilani, S Siddique, C Yap, J Khan… - Biology of Blood and …, 2016 - Elsevier
Disease relapse is the major causes of treatment failure after allogeneic stem cell
transplantation (SCT) in patients with acute myeloid leukemia (AML). As well as …

[HTML][HTML] Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte …

T Schroeder, E Rachlis, G Bug, M Stelljes… - Biology of Blood and …, 2015 - Elsevier
To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions
(DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation …

[HTML][HTML] Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission

AH Wei, H Döhner, C Pocock… - … England Journal of …, 2020 - Mass Medical Soc
Background Although induction chemotherapy results in remission in many older patients
with acute myeloid leukemia (AML), relapse is common and overall survival is poor …

[HTML][HTML] The QUAZAR AML-001 maintenance trial: results of a phase III international, randomized, double-blind, placebo-controlled study of CC-486 (oral formulation …

AH Wei, H Döhner, C Pocock, P Montesinos… - Blood, 2019 - Elsevier
Introduction: Many older patients (pts) with AML respond to intensive induction
chemotherapy (IC), but responses are often short-lived and overall survival (OS) is poor. The …

Extended dosing with CC‐486 (oral azacitidine) in patients with myeloid malignancies

MR Savona, K Kolibaba, P Conkling… - American journal of …, 2018 - Wiley Online Library
Abstract CC‐486 (oral azacitidine) is an epigenetic modifier in clinical development for
treatment of hematological cancers. This study of extended CC‐486 dosing included …