Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent
populations. It has high metastatic potential, with the lungs being the most common site of …

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular
mechanisms of etiology and pathogenesis, therefore it remains a challenge for current …

Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic
research has enabled a better understanding of OS pathogenesis and the discovery of new …

Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents. Despite significant clinical improvements over the past several decades …

Osteosarcoma, a highly malignant tumor, is characterized by widespread and recurrent
chromosomal and genetic abnormalities. In recent years, a number of elaborated …

Osteosarcoma is a relatively uncommon cancer, accounting for 5% of childhood cancers
and 8.9% of cancer-related deaths in children. The overall incidence is five cases per million …

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …

Background Osteosarcoma is a common primary malignant tumour of the bone that usually
occurs in children and adolescents. It is characterised by difficult treatment, recurrence and …

Background Human osteosarcoma is the most common pediatric bone tumor. There is
limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis …