The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …

Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …

Enhanced permeability and retention (EPR) effect is the physiology-based principal
mechanism of tumor accumulation of large molecules and small particles. This specific issue …

Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …

The enhanced permeability and retention (EPR) effect of solid tumors as seen with
nanomedicines and macromolecular drugs is well known. However, many researchers …

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor
interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This …

Malignant transformation and growth of the tumor mass tend to induce changes in the
surrounding microenvironment. Abnormality of the tumor microenvironment provides a …

Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …