Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in
cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM …

Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized
by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a …

Atherosclerosis-based vascular disease is an inflammatory disease characterized by
extensive remodeling of the extracellular matrix architecture of the arterial wall. Although …

Cathepsins, the lysosomal cysteine proteases, are involved in vascular remodeling and
atherosclerosis. Genetic knockout of cathepsins S and K in mice has shown to reduce …

Cathepsins are cysteine proteases that participate in various types of tissue remodeling.
However, their expressions during myocardial remodeling have not been examined. In this …

Background—Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-
profiling experiment that compared human early plaques, advanced stable plaques, and …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Atherosclerosis and diabetes are closely associated and both involve extensive degradation
of the aortic elastin. Increased elastase activity has been detected in diabetic animal aortae …

OBJECTIVE: Human atherosclerotic lesions overexpress elastolytic and collagenolytic
cathepsins with unclear pathological implications. The aim of this study was to investigate …

Context: Recent studies in humans and mice suggest the implication of the cysteine
proteases cathepsins S, L, and K in vascular and metabolic complications of obesity …