Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

Fluorinated compounds are finding increasing uses in several applications. They are
employed in almost all areas of modern society. These compounds are all produced by …

Nature has hardly evolved a biochemistry of fluorine although there is a low-level
occurrence of fluoroacetate found in selected tropical and subtropical plants. This …

Fluorine-containing compounds are widely used because they have properties required in
textiles and coatings for electronic, automotive, and outdoor products. However, fluorinated …

Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …

The fluorinase enzyme represents the only biological mechanism capable of forming stable
C–F bonds characterized in nature thus far, offering a biotechnological route to the …

In this paper, we report that fluoride ion is converted to the amino acid/antibiotic 4-
fluorothreonine 2 in a biotransformation involving five (steps a–e) overexpressed enzymes …

Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

The incorporation of fluorine has been shown to improve the biophysical and bioactive
properties of several organic compounds. However, sustainable strategies of fluorination are …