[HTML][HTML] SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
Dear Editor, Since the first outbreak in late 2019, the RNA genome of SARS-CoV-2 has
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
[HTML][HTML] Antiviral efficacy and safety of molnupiravir against omicron variant infection: a randomized controlled clinical trial
R Zou, L Peng, D Shu, L Zhao, J Lan, G Tan… - Frontiers in …, 2022 - frontiersin.org
Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has
unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved …
unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved …
[HTML][HTML] Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
Dear Editor, Omicron (B. 1.1. 529), is a heavily mutated and highly contagious SARS-CoV-2
variant, which is currently causing large outbreaks in many countries. Protection provided by …
variant, which is currently causing large outbreaks in many countries. Protection provided by …
Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant
Variants of SARS-CoV-2 have become a major public health concern due to increased
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal …
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal …
[HTML][HTML] Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection
B Gao, L He, Y Bao, Y Chen, G Lu, Y Zhang, Y Xu… - Cell Research, 2023 - nature.com
Dear Editor, Since the emergence of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in 2019, the virus has continued to evolve resulting in new waves of infection …
(SARS-CoV-2) in 2019, the virus has continued to evolve resulting in new waves of infection …
[HTML][HTML] Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance
R Flisiak, D Zarębska-Michaluk, M Rogalska… - Pharmacological …, 2022 - Springer
Background The real-world effectiveness of molnupiravir (MOL) during the dominance of
Omicron SARS-CoV-2 lineage is urgently needed since the available data relate to the …
Omicron SARS-CoV-2 lineage is urgently needed since the available data relate to the …
[HTML][HTML] Therapeutic efficacy of monoclonal antibodies and antivirals against SARS-CoV-2 Omicron BA. 1 in Syrian hamsters
R Uraki, M Kiso, M Imai, S Yamayoshi, M Ito… - Nature …, 2022 - nature.com
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
major antigen stimulating the host's protective immune response. Here we assessed the …
major antigen stimulating the host's protective immune response. Here we assessed the …
[HTML][HTML] Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model
K Rosenke, A Okumura, MC Lewis, F Feldmann… - JCI insight, 2022 - ncbi.nlm.nih.gov
The recent emergence of the SARS-CoV-2 Omicron variant of concern (VOC), which
contains a heavily mutated spike protein capable of escaping preexisting immunity …
contains a heavily mutated spike protein capable of escaping preexisting immunity …
[HTML][HTML] Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination
X Yu, D Wei, W Xu, Y Li, X Li, X Zhang, J Qu, Z Yang… - Cell Discovery, 2022 - nature.com
Dear Editor, As of December, 2021, more than 272 million people have been infected with
SARS-CoV-2. Multiple types of vaccines have been used to build herd immunity for the …
SARS-CoV-2. Multiple types of vaccines have been used to build herd immunity for the …
[HTML][HTML] Molnupiravir: from hope to epic fail?
D Focosi - Viruses, 2022 - mdpi.com
Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting
extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far …
extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far …
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