[HTML][HTML] Genetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
[HTML][HTML] Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
[HTML][HTML] Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals
Here we report a large genome-wide association study (GWAS) for longitudinal smoking
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …
Neuropsychosocial profiles of current and future adolescent alcohol misusers
A comprehensive account of the causes of alcohol misuse must accommodate individual
differences in biology, psychology and environment, and must disentangle cause and effect …
differences in biology, psychology and environment, and must disentangle cause and effect …
[HTML][HTML] Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …
the biology of complex traits, drug development and clinical guidelines. However, the …
Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use
Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …
in multiple loci. Rare variants within these loci hold promise in the identification of biological …
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
TE Thorgeirsson, F Geller, P Sulem, T Rafnar, A Wiste… - Nature, 2008 - nature.com
Smoking is a leading cause of preventable death, causing about 5 million premature deaths
worldwide each year,. Evidence for genetic influence on smoking behaviour and nicotine …
worldwide each year,. Evidence for genetic influence on smoking behaviour and nicotine …
A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations
Persistent tobacco use and excessive alcohol consumption are major public health
concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically …
concerns worldwide. Both alcohol and nicotine dependence (AD, ND) are genetically …