When to suspect a diagnosis of amyloidosis

I Vaxman, M Gertz - Acta Haematologica, 2020 - karger.com
Amyloidosis is a group of complex diseases caused by extracellular deposition of
pathological insoluble fibrillary protein in organs and tissues and may result in severe organ …

What is new in diagnosis and management of light chain amyloidosis?

G Palladini, G Merlini - Blood, The Journal of the American …, 2016 - ashpublications.org
Light chain (AL) amyloidosis is caused by a usually small plasma cell clone producing a
misfolded light chain that deposits in tissues. Survival is mostly determined by the severity of …

AL (light-chain) cardiac amyloidosis: a review of diagnosis and therapy

RH Falk, KM Alexander, R Liao, S Dorbala - Journal of the American …, 2016 - jacc.org
The amyloidoses are a group of protein-folding disorders in which≥ 1 organ is infiltrated by
proteinaceous deposits known as amyloid. The deposits are derived from 1 of several …

Recent advances in the diagnosis, risk stratification, and management of systemic light-chain amyloidosis

I Vaxman, M Gertz - Acta Haematologica, 2019 - karger.com
The term amyloidosis refers to a group of disorders in which protein fibrils accumulate in
certain organs, disrupt their tissue architecture, and impair the function of the effected organ …

New developments in diagnosis, risk assessment and management in systemic amyloidosis

I Vaxman, A Dispenzieri, E Muchtar, M Gertz - Blood reviews, 2020 - Elsevier
Amyloidosis is a group of disorders characterized by a misfolded protein that deposits in
organs and compromise their function. Clinician should have a high index of suspicion …

Immunoglobulin light-chain amyloidosis: from basics to new developments in diagnosis, prognosis and therapy

E Muchtar, FK Buadi, A Dispenzieri, MA Gertz - Acta haematologica, 2016 - karger.com
Immunoglobulin amyloid light-chain (AL) amyloidosis is the most common form of systemic
amyloidosis, where the culprit amyloidogenic protein is immunoglobulin light chains …

Current trends in diagnosis and management of cardiac amyloidosis

BL Esplin, MA Gertz - Current problems in cardiology, 2013 - Elsevier
Amyloidosis is a rare disease in which insoluble extracellular protein fibrils in β-pleated
sheets infiltrate multiple organs, causing organ dysfunction and failure. Amyloidoses are …

Amyloidosis: pathogenesis and new therapeutic options

G Merlini, DC Seldin, MA Gertz - Journal of Clinical Oncology, 2011 - ascopubs.org
The systemic amyloidoses are a group of complex diseases caused by tissue deposition of
misfolded proteins that results in progressive organ damage. The most common type …

Pitfalls in the diagnosis of primary amyloidosis

CE Chee, MQ Lacy, A Dogan, SR Zeldenrust… - … Myeloma and Leukemia, 2010 - Elsevier
Primary (AL) amyloidosis is the most prevalent type of systemic amyloidosis, and
management of this disease has evolved through the years from supportive care to …

Cardiac amyloid load: a prognostic and predictive biomarker in patients with light-chain amyloidosis

AV Kristen, E Brokbals, F aus dem Siepen… - Journal of the American …, 2016 - jacc.org
Background: Cardiac amyloid load has not been analyzed for its effect on mortality in
patients with amyloid light-chain (AL) cardiac amyloidosis. Objectives: This study …