Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

Heterocyclic scaffolds: centrality in anticancer drug development

I Ali, M Nadeem Lone, ZA Al-Othman… - Current drug …, 2015 - ingentaconnect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …

[图书][B] Heterocyclic chemistry in drug discovery

JJ Li - 2013 - books.google.com
Enables researchers to fully realize the potential to discover new pharmaceuticals among
heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this …

Modern advances in heterocyclic chemistry in drug discovery

AP Taylor, RP Robinson, YM Fobian… - Organic & …, 2016 - pubs.rsc.org
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …

A therapeutic journey of pyridine-based heterocyclic compounds as potent anticancer agents: a review (from 2017 to 2021)

M Alrooqi, S Khan, FA Alhumaydhi… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Pyridine derivatives are the most common and significant heterocyclic compounds, which
show their fundamental characteristics to various pharmaceutical agents and natural …

Advances in nano drugs for cancer chemotherapy

I Ali, K Salim, MA Rather, WA Wani… - Current cancer drug …, 2011 - ingentaconnect.com
In spite of some medications, millions of people are dying every year due to cancer.
Additionally, the survival patients suffer from various serious side effects due to the use of …

FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application

S Wang, XH Yuan, SQ Wang, W Zhao, XB Chen… - European Journal of …, 2021 - Elsevier
Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …

Comprehensive review on the Bis–heterocyclic compounds and their anticancer efficacy

MHA Al-Jumaili, AA Hamad, HE Hashem… - Journal of Molecular …, 2023 - Elsevier
Heterocyclic compounds are one of the largest family of organic compounds with broad
range of applications in medicinal chemistry and agrochemicals product. Bis-heterocycle …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …